PSENEN Antibody, HRP conjugated


SKUStock Size PriceQuantity
A69123-100ulAvailable100ul $299.00
A69123-50ulAvailable50ul $190.00
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Product Information

Aliases: Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2), PSENEN, PEN2
Product Type: Polyclonal Antibody
UnitprotID: Q9NZ42
Immunogen Species: Homo sapiens (Human)
Immunogen: Peptide sequence from Human Gamma-secretase subunit PEN-2 protein (39-57AA)
Host Species: Rabbit
Species Reactivity: Human
Applications: ELISA
Clonality: Polyclonal
Isotype: IgG
Conjugate: HRP
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form: Liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Purification Method: >95%, Protein G purified
Target Names: PSENEN
Research Areas: Neuroscience
Background: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).